Volume 23, Issue 5 p. 686-689
Free Access

Validity of the General Practice Research Database

Susan S. Jick D.Sc.

Corresponding Author

Susan S. Jick D.Sc.

Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts

Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421; e-mail: [email protected].Search for more papers by this author
James A. Kaye M.D., Dr.PH.

James A. Kaye M.D., Dr.PH.

Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts

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Catherine Vasilakis-Scaramozza M.P.H.

Catherine Vasilakis-Scaramozza M.P.H.

Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts

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Luis A. García Rodríguez M.D., M.Sc.

Luis A. García Rodríguez M.D., M.Sc.

Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain

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Ana Ruigómez M.D., Ph.D.

Ana Ruigómez M.D., Ph.D.

Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain

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Christoph R. Meier Ph.D., M.Sc.

Christoph R. Meier Ph.D., M.Sc.

Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Basel, Switzerland

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Raymond G. Schlienger Ph.D.

Raymond G. Schlienger Ph.D.

Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Basel, Switzerland

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Corri Black M.B.

Corri Black M.B.

Department of Public Health, Medical School, Aberdeen, Scotland

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Hershel Jick M.D.

Hershel Jick M.D.

Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts

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First published: 16 January 2012
Citations: 432

Abstract

The United Kingdom General Practice Research Database (GPRD) is an office-based, computer-generated, medical resource designed from its inception to be used for epidemiologic research. A distinct version of the GPRD is maintained by the Boston Collaborative Drug Surveillance Program and has been the source of more than 130 scientific articles primarily addressing drug safety issues. We reviewed evidence related to the validity of the GPRD. Specifically, with our extensive experience with this automated database, we evaluated the quality and completeness of the data that it contains.